Indications:-
Sheep
Gastrointestinal
roundworms
(adult and fourth-stage larvae):
Ostertagia circumcincta
including inhibited larvae
O. trifurcata
Haemonchus contortus
including inhibited larvae
Trichostrongylus axei
(adults)
T. colubriformis and T.
vitrinus (adults)
Cooperia curticei
Oesophagostomum
columbianum
O. venulosum (adults)
Nematodirus filicollis
Chabertia ovina
Trichuris ovis (adults).
Lungworms:
Dictyocaulus filaria
(adult and fourth-stage larvae)
Protostrongylus
rufescens (adults)
Nasal Bots (all larval
stages)
Oestrus ovis
Overdose (symptoms, emergency procedures,
antidotes), if necessary
Cattle: Single dose of 4.0 mg ivermectin
per kg (20 x the use level) given subcutaneously resulted in ataxia and
depression.
Pigs: A dose of 30 mg
ivermectin per kg (100 x the recommended dose of 0.3 mg per kg) injected
subcutaneously to pigs caused lethargy, ataxia, bilateral mydriasis,
intermittent tremors, laboured breathing and lateral recumbency.
Pharmacodynamic properties
Ivermectin is a member of the macrocyclic lactone class of
endectocides which have a unique mode of action. Compounds of the class bind
selectively and with high affinity to glutamate-gated chloride ion channels
which occur in invertebrate nerve and muscle cells. This leads to an increase
in the permeability of the cell membrane to chloride ions with
hyperpolarization of the nerve or muscle cell, resulting in paralysis and death
of the parasite. Compounds of this class may also interact with other
ligand-gated chloride channels, such as those gated by the neurotransmitter
gammaaminobutyric
(GABA). The margin of safety for compounds of this class is
attributable to the fact that mammals do not have glutamate-gates chloride
channels, the macrocyclic lactones have a low affinity for other mammalian
ligand-gated chloride channels and they do not readily cross the blood-brain
barrier
Dosage:
Poultry:
Internal Parasitism: 1 ml / 50
kg bodyweight.
External parasitism: 0.2mg/kg
bodyweight.
Sheep & Goat and
Cattle
The product should be
given only by oral route at the recommended dosage level of 200 mcg ivermectin
per kg bodyweight .
Each ml contains 10 mg
of ivermectin sufficient to treat 50 kg of bodyweight of cattle and sheep and
33 kg of bodyweight of pigs.
In young pigs,
especially those below 16 kg for which less than 0.5 ml of the product is
indicated, dosing accuracy is important.
In young lambs weighing
less than 20.0 kg give 0.1 ml per 5 kg.
Presentation
250ml, 100ml, 60ml,
30ml
