SULPHATRIM W.S.P

 Composition:   Each gram contains

 Sulfadiazine         100 mg

 Trimethoprim         20 mg

 Indications: A synergistic combination of bactericidal chemotherapeutics

The combination of trimethoprim and sulfadiazine acts synergistic and usually bactericidal against many Gram-positive and Gram-negative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, sheep, goats, poultry and swine.

 Both compounds affect bacterial purine synthesis in a different way, as a result, of which a double blockade is accomplished.

 Contra indications:

Hypersensitivity to trimethoprim and/or sulphonamides.
Administration to animals with a serious impaired renal and/or liver function or with blood dyscrasias.

 Side effects:

After long-term treatment and high dosages crystalluria can occur.
When symptoms of crystalluria occur (haematuria, kidney colic), treatment has to be stopped immediately and for example sodium carbonate (alkalinises) has to be administered for increasing urine solubility of sulfadiazine. Administration for a prolonged period also increases the risk for blood dyscrasias.
Anemia, leucopenia and thrombocytopenia.