NICLOZ-DS ORAL
SUSPENSION:
For treatment and control of gastro intestinal and pulmonary nematode
infections and chronic fascioliasis in cattle and sheep. It removes mature and
developing immature stages of range of nematode species.
COMPOSITION:
Each
ml contains
|
SNO
|
NAME
|
1ml
Content
|
Content
|
|
01
|
Oxyclozanide IP
|
60mg
|
6.0%
w/v
|
|
02
|
Levamisole
Hydrochloride IP
|
30mg
|
3.0%
w/v
|
|
04
|
Aqueous
Base
|
q.s
|
q.s
|
Indications:
The product is effective against the
following
In the abomasums: Haemonchus,
Ostertagia and Trichostronggylus spp.
In the intestines: Trichostronggylus,
Cooperia, Nematodirus, Oesphagostomum, Chabertia and
Bumostomumspp.
In the Lungs: Dictyocaulus.
It removes practically all adult flukes
(Fasciola Spp.) present in the bile ducts of the liver.
Effective against developing immature and
adult Ostertagia and in the treatment of Type II ostertagiasis in cattle;
however it is not effective against inhibited ostertagia larvae (Pre-type II
Ostertagiasis) in cattle and a later treatment may be necessary.
In sheep it is usually effective against
inhibited/arrested larvae of Haemonchus, Ostertagia and Trichostronggylus
axei.
Levamisole has been shown to be an effective
alternative treatment in cases where anthelmintic resistance has developed to
other chemically unrelated anthelmintic products.
Pharmacological
properties
Levamisole is the
laevo-enantiomer of tetramisole and is an anthelmintic imidazothiazole. It is effective upon oral against various
species of nematodes. Its anthemintic action is characterized by paralysis of
the worm through a neuromuscular inhibition of the depolarizing type, leading
to passive elimination of the worm. Oxyclozanide is an anthelmintic of the
salicylanilide group. It is effective against Fasciola species, acting as an
uncoupler of oxidative phosphorylation. It may act at more than one site to
decrease levels of ATP leading to metabolic malfunction and death of parasite.
Levamisole is rapidly
absorbed and peak plasma concentrations are attained within 1 to 3 hours after
dosing. Levamisole is rapidly distributed to all tissues, where levels are
several times higher than the corresponding
plasma levels. Elimination from plasma and tissue is also very rapid,
the main elimination route being urine(up to 50% of the dose with in 24 hours)
and the faeces (30% of the dose). The fraction of the unchanged parent drug in
the urine and bile is low as metabolisim is extensive.
Oxyclozanide is slowly absorbed after oral administration
with peak plasma levels 24 hours after dosing. Excretion is predominately
faecal.
