NICALBEND ORAL SUSPENSION:
Broad spectrum Sheep lamb and goat drench. For the
control of susceptible gastro intestinal roundworms, large lungworms, tapeworms and to
aid in the control of adult liver fluke. Also to reduce the output of viable
worm and fluke eggs.
COMPOSITION:
Each ml contains
|
SNO
|
NAME
|
1ml
Content
|
Content
|
|
01
|
Niclosamide IP
|
100mg
|
10.0%
w/v
|
|
02
|
Albendazole IP
|
30mg
|
3.0%
w/v
|
|
03
|
Colour
Tartrazine
|
|
|
|
04
|
Aqueous
Base
|
q.s
|
q.s
|
INDICATIONS:ALBENDAZOLE
Albendazole is approved for the
following endoparasites of sheep and cattle: Ostertagia
ostertagi, Haemonchus spp., Trichostrongylus spp., Nematodius spp., Cooperia spp.,
Bunostomum phlebotomum, Oesphagostomum spp., Dictacaulus
spp., Fasciola hepatica (adults),
and Moniezia spp. It is also used in sheep, goats and swine for
endoparasite control.
In cats, albendazole has been used to treat Paragonimus kellicotti infections. In dogs and cats,
albendazole has been used to treat capillariasis. In
dogs, albendazole has been used to treat
Filaroides infections.
Albendazole was implicated as being an oncogen in 1984, but subsequent studies
were unable to demonstrate any oncogenic or carcinogenic activity of the drug.
INDICATIONS:
NICLOSAMIDE
Active against Tapeworm and intestinal
Flukes such as Paramphistomes in ruminants .Effective against mature and immature Tapeworms (Scolex
and segment) in Sheep, Goat, Cattle, Poultry etc.
Pharmacological
properties
Benzimidazoles binds
to beta-tubulin (a structural protein) and blocks polymerization of tubulin
into microtubules. This damages the integrity and transport function of cells
within the parasite.the antiparasitic effect is a lethal.
Niclosamide inhibits oxidative phosphorylation in
mitochondria of cestodes; anaerobic metabolism, on which many cestodes are
dependent, may also be inhibited; scolex and proximal proglottids are killed on
contact; scolex is loosened from intestinal wall and may be digested.
