RAPIGEST(DIGESTIVE TONIC)

Solution for oral administration

Compositions:

Contains

Sorbitol

Betaine

D-Panthenol

Choline chloride

Magnesium sulphate

Carnitine hydrochloride

Solvents ad qs.

 Description:

Digestive tonic is a combination of compounds aimed at optimization of the liver function and prevention and correction of fat deposits.

Free fatty acids are partly metabolized in the liver to form triglycerides, which may be stored in the hepatocytes causing fatty liver when an imbalance exists among uptake, synthesis, export and oxidation of fatty acids.

Carnitine, betaine, choline and D-Panthenol are key metabolites involved in these processes,affecting the influx of free fatty acids to the liver, free fatty acid a-oxidation, the hepatic secretion of triglycerides and lipid peroxidation.

Carnitine is an amino acid derivative, synthesized in vivo from methionone and lysine. Its main function is to facilitate lilid oxidation by transporting long-chain fatty acids into the inner mitochonondria region where they undergo a-oxidation. Consequently, in case of carnitine deficiencies, most of the dietary lipids nay not be used as an energy source and accumulate in the animal’s body leading to unwanted fat deposits. In addition, it aids in the removal of short and medium –chain fatty acids that accumulate in mitochondria as a result of normal or abnormal metabolism. Depending on the dietary adaptation to carnitine and the nature of the diet fed, carnitine is degraded to some extent in ruminal fluid.

Sorbitol and magnesium act as osmotic laxative in order to facilitate the elimination of toxic products from the gastrointestinal tract. In addition, magnesium has an important function as a constituent of enzymes involved in the synthesis and metabolism of carbohydrates, lipids, proteins, and nucleic acids

Choline is an organic compound, classified as a water-soluble essential nutrient and usually grouped within the vitamin B-Complex. This natural amine is found in the lipids that make up cell membranes and in the neurotransmitter acetylcholine.

Choline and its metabolited are needed for three main physiological purposes:

Structural intergrity and signaling roles for cell membranes.

Cholinergic neurotransmission(acetylcholine synthesis)

As a major source of methyl groups via its metabolite, trimethylglyycine(betaine),that participates in fat metabolism viat the Sadenosymethionine synthesis pathways. As a result, choline deficiency may lead to an abnormal accumulation of fat in the liver, reduced growth rates and musle control, kidney damage, perosis and decreased egg production and hatchability.

Indications:

Digestive tonic is a dietetic liquid supplement formulated to correct fatty liver conditions, prevent liver dysfunction and correct

 digestive disturbances in animal when fed a lithogenic diet(high in  oil, fat cholesterol and cholic acid) leading to an increased supply of free fatty acids

to hepatic cells, or when the conditions are such that increased released reales of fatty acids from adipose tissue take place

side effects

No undesirable effects are to be expected when the prescribed dosage regimen is followed